STAT 4 T Cell + IL - 12 - Programmed Long - Term CD 8

of April 14 , 2017 . This information is current as Responses Require STAT 4 T Cell + IL - 12 - Programmed Long - Term CD 8

of April 30 , 2017 . This information is current as Responses Require STAT 4 T Cell + IL - 12 - Programmed Long - Term CD 8 Shrikant

Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa.

BACKGROUND In coeliac disease (CD) mucosa, the histological lesion is associated with marked infiltration of T helper cell type 1 (Th1) cells. However, the molecular mechanisms which regulate Th1 cell differentiation in CD mucosa are unknown. AIMS To analyse expression of transcription factors which control the Th1 cell commitment in CD. PATIENTS Duodenal mucosal samples were taken from unt...

COELIAC DISEASE Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa

Background: In coeliac disease (CD) mucosa, the histological lesion is associated with marked infiltration of T helper cell type 1 (Th1) cells. However, the molecular mechanisms which regulate Th1 cell differentiation in CD mucosa are unknown. Aims: To analyse expression of transcription factors which control the Th1 cell commitment in CD. Patients: Duodenal mucosal samples were taken from untr...

STAT3, STAT4, NFATc1, and CTCF regulate PD-1 through multiple novel regulatory regions in murine T cells.

Programmed death-1 (PD-1) is a crucial negative regulator of CD8 T cell development and function, yet the mechanisms that control its expression are not fully understood. Through a nonbiased DNase I hypersensitivity assay, four novel regulatory regions within the Pdcd1 locus were identified. Two of these elements flanked the locus, bound the transcriptional insulator protein CCCTC-binding facto...